WASHINGTON (AP) ? Recalling the shooting of 20 first graders as the worst day of his presidency, President Barack Obama on Sunday pledged to put his "full weight" behind a legislative package next year aimed at containing gun violence.
In an interview with NBC's "Meet the Press," Obama voiced skepticism about proposals to place armed guards at schools in the aftermath of the Dec. 14 deadly assault at Sandy Hook Elementary School in Newtown, Conn.
In his boldest terms yet, he vowed to rally the American people around an agenda to limit gun violence and said he still supports increased background checks and bans on assault weapons and high capacity bullet magazines.
"It is not enough for us to say, 'This is too hard so we're not going to try,'" Obama said. "So what I intend to do is I will call all the stakeholders together. I will meet with Republicans. I will meet with Democrats. I will talk to anybody.
"I think there are a vast majority of responsible gun owners out there who recognize that we can't have a situation in which somebody with severe psychological problems is able to get the kind of high capacity weapons that this individual in Newtown obtained and gun down our kids. And, yes, it's going to be hard."
Obama's comments come as the schoolroom shooting has elevated the issue of gun violence to the forefront of public attention.
Six adults also died at the school. Authorities say the shooter killed himself and also killed his mother at their home.
The slayings have prompted renewed calls for greater gun controls. The National Rifle Association has resisted those efforts vociferously, arguing instead that schools should have armed guards for protection.
"I am skeptical that the only answer is putting more guns in schools," Obama said. "And I think the vast majority of the American people are skeptical that that somehow is going to solve our problem."
Obama said he intended to press the issue with the public.
"Will there be resistance? Absolutely there will be resistance," he said.
"The question then becomes whether we are actually shook up enough by what happened here that it does not just become another one of these routine episodes where it gets a lot of attention for a couple of weeks and then it drifts away. It certainly won't feel like that to me. This is something that - you know, that was the worst day of my presidency. And it's not something that I want to see repeated."
Besides getting gun violence legislation passed next year, Obama also listed immigration as a top priority for 2013 as well as deficit reduction. A big deficit reduction deal with Republicans proved elusive this month and Obama is now hoping Senate Democratic and Republican leaders salvage a scaled back plan that avoids across the board tax increases for virtually all Americans.
He issued a defense of former Republican Sen. Chuck Hagel of Nebraska, who has been mentioned as one of the leading candidates for new secretary of defense.
Hagel, who opposed President George W. Bush's decision to go to war with Iraq, has been criticized in conservative circles for not being a strong enough ally of Israel. Many liberals and gay activists also have banded against him for comments he made in 1998 about an openly gay nominee for an ambassadorship
Obama, who briefly served with Hagel in the Senate, stressed that he had yet to make a decision on a secretary of defense but said called Hagel a "patriot."
"He is somebody who has done extraordinary work both in the United States Senate," he said. "Somebody who served this country with valor in Vietnam. And is somebody who's currently serving on my intelligence advisory board and doing an outstanding job."
He noted that Hagel had apologized for his 14-year-old remark. "And I think it's a testimony to what has been a positive change over the last decade in terms of people's attitudes about gays and lesbians serving our country," Obama said.
A great way to turn your life around for the better is through personal development. Brainstorming with yourself about the areas you want to change for the better is a great way to start a self improvement project. In this article we will provide you with some solid advice about implementing self help tips in to your life.
No matter what, you must adhere to one rule. It is important that you be an active participant in living your life. Watching from the sidelines serves no good purpose. Being a passive observer to the world around you removes you from the game entirely. Do not let that happen.
One way to raise your self-esteem is to give other people compliments. You can reverse the process, though. Being kind and positive to other people puts you in a good mindset and encourages you to treat yourself right.
By being a leader, you can help improve your self improvement. Leadership is generally approached as being influential. Take a look at your leadership journey. Which past events have had major, formative effects on your life? How have these events transcended the life that you live? What personality characteristics define you as a team player? By carefully evaluating these questions, you can increase your awareness of your ability to function well in a team setting.
Sexual capitol is a new trait researchers have just discovered, and they feel it is important to have. This means to use your skills to charm others to get the things you want in life rather than your sexuality. Good social skills are not something everyone is born with, but developing them help you go the distance in life.
The success of your personal development efforts is directly tied to the research and work you put into improving yourself. Further, you must be persistent with your efforts if you want them to pay off. You will find a great sense of accomplishment if you follow some of the wonderful tips above.
For one, it?s a long and soft word, full of hissing and seething noises, so it?s naturally unpleasant to hear. ?We like our soft words to be short, the better to convey the impact of their message, like ?love.? ?And we like our long words to have hard sounds in them so that they seem to have a foundation when they start to wobble under the weight of their syllables, like ?conflict.?
But the real reason we don?t like the word ?relationship? is that it?s too weak to convey the dire severity of its meaning. ?We have a warped definition of the word, one that conjures up images of Zach Braff agonizing through internal dialogue in a hospital cafeteria or an entire genre of books based around women standing around, waiting to see which werewolf or vampire will be the one to take her home.
I once received a review that bemoaned the sheer amount of ?relationship stuff? in?Black Halo. ?It was distinctly critical of how much time was spent getting the characters to know each other better and what they were doing as despair set in. ?His praise finally picked up when Lenk charged heedlessly onto a boat to save Kataria and kill people, which is when he said something along the lines of ?this is what it?s all about. ?Not relationships, but adventure and fighting.?
I kind of sighed.
Not that I blamed him. ?I don?t blame any critic for their views. ?But even if I did, I wouldn?t have blamed him for operating under a weird (if widespread) definition of the word ?relationship.?
We are raised with the belief that ?relationship? is a word that means ?solution.? ?You are not a normal person until you have a long-term relationship, according to the media. ?You are not a well-adjusted human being unless you have a good relationship with your family. ?You are incomplete until you can sit down, watch a shitty sitcom and get the ?jokes? that revolve around a woman wanting a man to buy tampons and him wanting to watch football instead. ?And if you are not normal, well-adjusted or complete, then you surely will be once you get a relationship, because that?s what normal people do.
And likewise, we are raised with the belief that ?conflict? is a word that means ?problem.? ?Conflicts are things that do not occur naturally. ?Conflicts happen because someone screwed up. ?Conflicts are problems to be solved. ?We define our stories with words like ?Man vs. Self,? ?Man vs. Man,? ?Man vs. Manatee? and the like with the implication that they will be overcome.
Conflicts are what define our stories.
But ?conflict? and ?relationship? mean the same thing.
The reason we don?t like the word ?relationship? is because society?s definition of it as ?solution? does not actually fit with what a relationship is. ?And what a relationship is is adversarial in nature. ?It is there to change the status quo, to push people toward each other or away from each other, to disrupt what is comfortable and create something different.
And that?s painful. ?Sometimes exceedingly so.
Because, win or lose, we don?t get to walk away from relationships unchanged. ?We can underplay violence pretty well in society and especially in fantasy literature. ?We throw in fight scenes with the expectation that victory for our heroes means the return of the status quo. ?The dragon is dead, so everything can go back to normal. ?We haven?t yet figured out a way to do this with relationships.
Nor should we.
Every story is about relationships. ?Every boat, sword, laser, ghost, dragon, demon or zeppelin is just a means of pushing that relationship forward.
And I don?t think I really understood this when I started writing.
I think, when I began with?Tome of the Undergates,?I viewed battles and relationships as separate entities. ?We had our fight scenes, then we had our talk scenes, then we had our fight scenes and then talking. ?It was easily staggered and people could skip parts they didn?t like. ?That?s not good writing.
In?Black Halo,?I think I stumbled around the truth a little. ?I knew that fight scenes were just dialogue with fists, that there should never be a fight scene that didn?t change the conversation in some direction. ?I knew that relationships were what broke people, not blood or swords. ?I knew that a woman turning her back on you was worse than a knife embedded in your shoulder. ?But I didn?t know how to express that.
It got better in?The Skybound Sea.
But I think it?s only at my current project that I understand how to make ?relationship? mean ?conflict? mean ?problem and solution.? ?I only now understand what it means to make two people love and hate each other at the same time. ?I only now understand what it means when battle is an extension of love, when swords are long kisses and blood drops are notes in a love song.
Love. ?Hate. ?Relationship. ?Conflict.
They all basically means the same thing: change. ?Change is scary. ?But meaningful.
?Relationships? as we know them by the society?s definition are not meaningful. ?Society tells us that a relationship is a comfort, a normalcy, a solution.
Were that true, we would never feel our hearts beat faster when someone took a step closer to us, we would never listen to the radio and wonder what they were talking about when they played a love song from fifty years ago, we would never lie awake at night wondering how long we could go on being alone.
?Conflicts? as we know them by society?s definition are not meaningful. ?Society tells us that a conflict is a burden, an error, a problem.
Were that true, we would never spend our time consumed with thoughts as to how to punish those who have wronged us, we would never devote more energy to defining ourselves by what we want not to be than we do about what we?do?want to be, we would never look at an enemy and realize we were still alone.
But society is wrong. ?Literature is right.
Relationships are everything. ?Conflict is everything. ?Comfort means nothing. ?Change means everything.
Penn team mimicking a natural defense against malaria to develop new treatmentsPublic release date: 27-Dec-2012 [ | E-mail | Share ]
Contact: Karen Kreeger karen.kreeger@uphs.upenn.edu 215-349-5658 University of Pennsylvania School of Medicine
PHILADELPHIA - One of the world's most devastating diseases is malaria, responsible for at least a million deaths annually, despite global efforts to combat it. Researchers from the Perelman School of Medicine at the University of Pennsylvania, working with collaborators from Drexel University, The Children's Hospital of Philadelphia, and Johns Hopkins University, have identified a protein in human blood platelets that points to a powerful new weapon against the disease. Their work was published in this months' issue of Cell Host and Microbe.
Malaria is caused by parasitic microorganisms of the Plasmodium genus, which infect red blood cells. Recent research at other universities showed that blood platelets can bind to infected red blood cells and kill the parasite, but the exact mechanism was unclear. The investigators on the Cell Host and Microbe paper hypothesized that it might involve host defense peptides (HDP) secreted by the platelets.
"We eventually found that a single protein secreted when platelets are activated called human platelet factor 4 [hPF4] actually kills parasites that are inside red cells without harming the red cell itself," explains senior author Doron Greenbaum, PhD, assistant professor of Pharmacology, whose team studies innovative ways to fight malaria. The hPF4 targets a specific organelle of the Plasmodium falciparum parasite called the digestive vacuole, which essentially serves as its "stomach" for the digestion of hemoglobin. The investigators found that hPF4 destroys the vacuole with a deadly speed of minutes or even seconds, killing the parasite without affecting the host cell.
While host defense peptides appear to be attractive therapeutic agents, the expense of manufacturing this protein lessens its potential impact on the treatment of malaria. Greenbaum and colleagues set out to discover whether synthetic molecules mimicking the structure of HDPs could have similar beneficial effects against the Plasmodium parasite. After screening approximately 2000 small molecule HDP mimics (smHDPs) developed by biotech company PolyMedix, Inc. of Radnor, PA, Greenbaum and his team found that "all of the best hits had the same mechanism of action against Plasmodium parasites."
Like the natural hPF4 found in platelets, the most effective smHDPs tested targeted only infected red blood cells, attacking and destroying the parasite in exactly the same way, but with even greater potency and speed. "The smHDPs get into infected red cells and lyse or basically destroy the digestive vacuole or stomach of the parasite more rapidly than the hPF4 protein," Greenbaum notes. "The protein from platelets is about 25 times less potent, but the surprising thing is they act with the same mechanism. With ease, within seconds, they destroy the vacuole of the parasite."
Greenbaum's team settled on two compounds, PMX1207 and PMX207, for testing in mouse models of malaria. Both compounds significantly decreased parasitic growth and greatly improved survival rates, providing further confirmation of the potential of smHDPs as antimalarial agents. The work, Greenbaum says, shows that "we can translate a natural arm of the innate immune system in platelets to drug-like small molecules that we are honing to become potent, selective, potentially less toxic, and cheaper to make as an antimalarial."
Aside from their great effectiveness, smHDPs may have several other advantages over other antimalarial therapies. As Plasmodium inevitably adapts and becomes resistant to a particular drug therapy, the efficacy of that treatment decreases and survival rates drop. By mimicking the body's own natural defenses, the new HDP-centered approach could avoid that pitfall. "Certainly with malaria we've had a lot of problems in the last 20 years with resistance," Greenbaum explains. "One of the unique features of the synthetic HDPs is that studies show that pathogens have a difficult time generating resistance to them, because they attack membranes, not proteins. So they might be intrinsically more difficult to become resistant against."
Although Greenbaum's team focused mostly on the chronic red-blood-cell stage of malaria, their HDP-mimic also shows promise against other stages of the disease. "We think that the mimics would be useful as a transmission-blocking therapeutic," Greenbaum says. "In other words, you prevent transmission from human to mosquito and therefore back to human again. We have positive data for those two stages. It's becoming increasingly more important in antimalarial drug development that people think more and more about multistage inhibition."
The next step for Greenbaum's team is to further hone the selectivity and potency of the smHDP compounds, while developing them into drugs that can be orally administered. As Greenbaum explains, practical antimalarials need to be "taken as pills rather than having to be used intravenously, which is not going to be appropriate for treatment in endemic countries, especially in more rural environments."
###
Co-authors are Melissa S. Love, Melanie G. Millholland, Satish Mishra, Swapnil Kulkarni, Katie B. Freeman, Wenxi Pan, Robert W. Kavash, Michael J. Costanzo, Hyunil Jo, Thomas M. Daly, Dewight R. Williams, M. Anna Kowalska, Lawrence W. Bergman, Mortimer Poncz, William F. DeGrado, Photini Sinnis, and Richard W. Scott.
The research was funded by the National Institutes of Health (R44 AI090762-0; NIHT32GM08076; NIHT32AI007532; R01 AI056840); a Penn TAPITMAT Pilot Program; the Penn Genome Frontiers Institute; and a Gates Grand Challenges Exploration Program.
Penn Medicine is one of the world's leading academic medical centers, dedicated to the related missions of medical education, biomedical research, and excellence in patient care. Penn Medicine consists of the Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania (founded in 1765 as the nation's first medical school) and the University of Pennsylvania Health System, which together form a $4.3 billion enterprise.
The Perelman School of Medicine is currently ranked #2 in U.S. News & World Report's survey of research-oriented medical schools. The School is consistently among the nation's top recipients of funding from the National Institutes of Health, with $479.3 million awarded in the 2011 fiscal year.
The University of Pennsylvania Health System's patient care facilities include: The Hospital of the University of Pennsylvania -- recognized as one of the nation's top "Honor Roll" hospitals by U.S. News & World Report; Penn Presbyterian Medical Center; and Pennsylvania Hospital the nation's first hospital, founded in 1751. Penn Medicine also includes additional patient care facilities and services throughout the Philadelphia region.
Penn Medicine is committed to improving lives and health through a variety of community-based programs and activities. In fiscal year 2011, Penn Medicine provided $854 million to benefit our community.
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Penn team mimicking a natural defense against malaria to develop new treatmentsPublic release date: 27-Dec-2012 [ | E-mail | Share ]
Contact: Karen Kreeger karen.kreeger@uphs.upenn.edu 215-349-5658 University of Pennsylvania School of Medicine
PHILADELPHIA - One of the world's most devastating diseases is malaria, responsible for at least a million deaths annually, despite global efforts to combat it. Researchers from the Perelman School of Medicine at the University of Pennsylvania, working with collaborators from Drexel University, The Children's Hospital of Philadelphia, and Johns Hopkins University, have identified a protein in human blood platelets that points to a powerful new weapon against the disease. Their work was published in this months' issue of Cell Host and Microbe.
Malaria is caused by parasitic microorganisms of the Plasmodium genus, which infect red blood cells. Recent research at other universities showed that blood platelets can bind to infected red blood cells and kill the parasite, but the exact mechanism was unclear. The investigators on the Cell Host and Microbe paper hypothesized that it might involve host defense peptides (HDP) secreted by the platelets.
"We eventually found that a single protein secreted when platelets are activated called human platelet factor 4 [hPF4] actually kills parasites that are inside red cells without harming the red cell itself," explains senior author Doron Greenbaum, PhD, assistant professor of Pharmacology, whose team studies innovative ways to fight malaria. The hPF4 targets a specific organelle of the Plasmodium falciparum parasite called the digestive vacuole, which essentially serves as its "stomach" for the digestion of hemoglobin. The investigators found that hPF4 destroys the vacuole with a deadly speed of minutes or even seconds, killing the parasite without affecting the host cell.
While host defense peptides appear to be attractive therapeutic agents, the expense of manufacturing this protein lessens its potential impact on the treatment of malaria. Greenbaum and colleagues set out to discover whether synthetic molecules mimicking the structure of HDPs could have similar beneficial effects against the Plasmodium parasite. After screening approximately 2000 small molecule HDP mimics (smHDPs) developed by biotech company PolyMedix, Inc. of Radnor, PA, Greenbaum and his team found that "all of the best hits had the same mechanism of action against Plasmodium parasites."
Like the natural hPF4 found in platelets, the most effective smHDPs tested targeted only infected red blood cells, attacking and destroying the parasite in exactly the same way, but with even greater potency and speed. "The smHDPs get into infected red cells and lyse or basically destroy the digestive vacuole or stomach of the parasite more rapidly than the hPF4 protein," Greenbaum notes. "The protein from platelets is about 25 times less potent, but the surprising thing is they act with the same mechanism. With ease, within seconds, they destroy the vacuole of the parasite."
Greenbaum's team settled on two compounds, PMX1207 and PMX207, for testing in mouse models of malaria. Both compounds significantly decreased parasitic growth and greatly improved survival rates, providing further confirmation of the potential of smHDPs as antimalarial agents. The work, Greenbaum says, shows that "we can translate a natural arm of the innate immune system in platelets to drug-like small molecules that we are honing to become potent, selective, potentially less toxic, and cheaper to make as an antimalarial."
Aside from their great effectiveness, smHDPs may have several other advantages over other antimalarial therapies. As Plasmodium inevitably adapts and becomes resistant to a particular drug therapy, the efficacy of that treatment decreases and survival rates drop. By mimicking the body's own natural defenses, the new HDP-centered approach could avoid that pitfall. "Certainly with malaria we've had a lot of problems in the last 20 years with resistance," Greenbaum explains. "One of the unique features of the synthetic HDPs is that studies show that pathogens have a difficult time generating resistance to them, because they attack membranes, not proteins. So they might be intrinsically more difficult to become resistant against."
Although Greenbaum's team focused mostly on the chronic red-blood-cell stage of malaria, their HDP-mimic also shows promise against other stages of the disease. "We think that the mimics would be useful as a transmission-blocking therapeutic," Greenbaum says. "In other words, you prevent transmission from human to mosquito and therefore back to human again. We have positive data for those two stages. It's becoming increasingly more important in antimalarial drug development that people think more and more about multistage inhibition."
The next step for Greenbaum's team is to further hone the selectivity and potency of the smHDP compounds, while developing them into drugs that can be orally administered. As Greenbaum explains, practical antimalarials need to be "taken as pills rather than having to be used intravenously, which is not going to be appropriate for treatment in endemic countries, especially in more rural environments."
###
Co-authors are Melissa S. Love, Melanie G. Millholland, Satish Mishra, Swapnil Kulkarni, Katie B. Freeman, Wenxi Pan, Robert W. Kavash, Michael J. Costanzo, Hyunil Jo, Thomas M. Daly, Dewight R. Williams, M. Anna Kowalska, Lawrence W. Bergman, Mortimer Poncz, William F. DeGrado, Photini Sinnis, and Richard W. Scott.
The research was funded by the National Institutes of Health (R44 AI090762-0; NIHT32GM08076; NIHT32AI007532; R01 AI056840); a Penn TAPITMAT Pilot Program; the Penn Genome Frontiers Institute; and a Gates Grand Challenges Exploration Program.
Penn Medicine is one of the world's leading academic medical centers, dedicated to the related missions of medical education, biomedical research, and excellence in patient care. Penn Medicine consists of the Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania (founded in 1765 as the nation's first medical school) and the University of Pennsylvania Health System, which together form a $4.3 billion enterprise.
The Perelman School of Medicine is currently ranked #2 in U.S. News & World Report's survey of research-oriented medical schools. The School is consistently among the nation's top recipients of funding from the National Institutes of Health, with $479.3 million awarded in the 2011 fiscal year.
The University of Pennsylvania Health System's patient care facilities include: The Hospital of the University of Pennsylvania -- recognized as one of the nation's top "Honor Roll" hospitals by U.S. News & World Report; Penn Presbyterian Medical Center; and Pennsylvania Hospital the nation's first hospital, founded in 1751. Penn Medicine also includes additional patient care facilities and services throughout the Philadelphia region.
Penn Medicine is committed to improving lives and health through a variety of community-based programs and activities. In fiscal year 2011, Penn Medicine provided $854 million to benefit our community.
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Magnetic levitation is central to the fastest trains we know today, but it's that dependence on electromagnets and rails that limits how and where it's used for transportation. Aoyama Gakuin Universityhas a unique alternative: changing the material properties themselves. By floating graphite over a bed of circular magnets, taking advantage of its tendency to generate an opposing magnetic field, researchers can move the graphite just by blasting its edge with a laser. The heat skews the magnetic behavior of that area enough to unbalance the graphite, either in a specific direction or a spin. The research team believes it could lead to maglev transportation or even energy converting turbines that are steered solely by light, with no contact or outside guides: maglev vehicle pilots could have much more control over where they go. Getting to that point will require a much larger scale, but successful development could give technology a very literal lift.
A rare landslide and rockfall warning has been issued for south-west England by the British Geological Survey (BGS).
The BGS has concerns about the stability of cliff edges and cliff sides because of the quantity and intensity of the recent heavy rain.
It is worried about people going for Boxing Day walks, and is advising extra caution near cliff edges.
Meanwhile, there are weather warnings for rain and flooding in England and icy roads in northern Scotland.
The British Geological Survey (BGS), along with other agencies, feeds information into the Hazard Warning Centre at the Met Office in Exeter.
The South West Coastal Path, which covers most of the Dorset, Devon, Cornwall and Somerset coasts, runs through areas which are potentially at risk.
The Met Office said an area of heavy rain would move across the country during Wednesday. It said that given the continuing saturated state of the ground this may lead to further localised flooding.
There is also a warning of icy roads for the Shetland Isles, the Orkney Isles and north-eastern parts of Scotland.
Icy stretches are expected to form overnight, especially on surfaces where showers have washed off salt treatments. The Met Office said this could lead to difficult driving conditions.
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Elsewhere:
The Environment Agency has 151 flood warnings and 252 flood alerts in place in England and Wales. There are no flood warnings in Scotland.
Weather forecasters have predicted that wet weather is set to continue until at least Friday, potentially bringing further flooding to parts of the UK.
The Environment Agency has said many places will stay on flood alert despite a slight easing of weather conditions.
Met Office figures suggest 2012 is set to be one of the wettest years since records began in 1910.
Before December, the average rainfall for the year so far was 1,202mm - placing it 13th in the list of wettest years.
Due to the deluge of rain in the run up to Christmas, forecasters say 2012 is now likely to finish with one of the highest rainfall totals on record.
The year 2000 remains the UK's wettest year, with an average rainfall of 1,337mm.
Continue reading the main story
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(CNN) ? You may not know his name, but anyone who watches movies and television knows the squat, tough-faced character actor Charles Durning, who died on Christmas Eve, according to his family.
The 89-year-old decorated World War II veteran had an award-winning career that spanned 20th Century entertainment, from the burlesque stage and theater to television and film, playing roles as diverse as society itself.
Durning was the gruff father smitten by Dustin Hoffman?s female impersonation of ?Tootsie,? the Southern politician dancing on stage with George Clooney?s Soggy Bottom Boys in ?O Brother, Where Art Thou?? and the corrupt cop caught up in the ?big con? by Paul Newman and Robert Redford in ?The Sting.?
He won Tony and Golden Globe awards and was nominated for Academy Awards two times as a supporting actor. He also received nine Emmy nominations and was honored in 2007 with a lifetime achievement award from the Screen Actors Guild.
Born in Highland Falls, New York, on February 28, 1923, Durning became an actor relatively late.
According to his TV Guide biography, Durning left home at age 16 and later enlisted in the Army. Durning landed on Normandy beach on D-Day and fought in the Battle of the Bulge, receiving the Silver Star and three Purple Hearts.
He worked odd jobs that ranged from professional boxing to teaching ballroom dancing to ushering in a burlesque house, where he got his start on stage by once filling in for a comic who failed to show up, the actor often recalled.
He also attended the American Academy of Dramatic Arts, where he trained with Jason Robards, Colleen Dewhurst and others.
Some of Durning?s other best-known roles included his Tony-winning performance as Big Daddy in ?Cat on a Hot Tin Roof?, the governor in ?Best Little Whorehouse in Texas?, a beleaguered police officer in ?Dog Day Afternoon? and as Doc Hopper, the owner of a frog leg restaurant in ?The Muppet Movie.?
Durning?s family, in a statement issued Tuesday, said, ?Not only was Charlie a World War II hero but he was also a hero to his family. Charlie loved Christmas and if he could have chosen a time to pass, he would have chosen this day.?
By Tom Cohen, CNN
? & ? 2012 Cable News Network, Inc., a Time Warner Company. All rights reserved.
What kind of benefits can you gain from creating high quality content? Ooops, that isn?t the question? Your reader doesn?t care about YOU. They want to know what benefits you provide them. Article Marketing isn?t about you, it?s about them. Can you answer their question, or are they stuck listening to how you?ll be benefiting from their presence on your site.
8 seconds isn?t enough to tell your reader about your business, nor is it enough to gain any insight into their interest in your business, but it?s all their willing to spend on you, unless you tell them what they can gain by being there. Give them value, content, and benefits on the front page.
Appealing to the eye:
Give them eye candy to capture their interest in the early part of your presentation. Make it attractive to view your content, easy to read, personable and striking to look at, with key components that capture their interest. Color, easy on the eye fonts, directly related keyword emphasis, and simple style formats will keep them looking for more.
Highlighted subtitles:
Once they get past the main title, which should grab their attention instantly, you?ll need to provide quick and easy to read subtitles that keep them scanning the page. Immediately after the first or second paragraph, above the fold, give them a second header that says something of value. Use keywords, or at very least attractive words.
Captivating content they require:
Give them what they want. If you haven?t figured it out yet, most people really do want FREE or low cost product, they have enough of the big bills, so give them VALUE at low cost. You might be able to sell your high dollar products after you capture their interest and gain their trust, but in the beginning, make it affordable or free to help bring them in. Give them the valuable content they?re looking for.
Are you ready to share some benefits?
Present your benefits in 2 FREE Article Templates from http://advertizeyourbusiness.com and get a FREE Subscription to ADvertiZe ezine.
Here are the stories you clicked on the most on our site
By The Editors
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1. hanbroekman 07:38 AM 12/24/12
The link for #1 is wrong
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2. Chryses 07:56 AM 12/24/12
Yes. #4. How Hollywood Is Encouraging Online Piracy, was n eye-opener for me.
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3. Stagnaro 10:20 AM 12/24/12
Admittedly, all most popular American Sceintific Stories are really interesting and fascinating. However, I find both enlightening and preoccupaying that readers showed to be no interested in papers suggesting new road, clinical in nature, in the war against today's growing epidemics, as CAD, type 2 DM, and Cancer.
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4. jtdwyer 03:28 PM 12/24/12
At least 'Zip past' was only mistyped "Zippast" in this link to article #7...
The NOPD is seeking a missing 11-year-old girl from Algiers. Emyri Smith was last seen about 5 p.m. Friday at her mother's house in the 2000 block of Lebouf Street, police said.
Smith's mother said she assumed her daughter had gone with her younger sister to a store and later to a neighborhood friend's house. When the mother's younger daughter returned home Saturday about 6 p.m., the mother learned Emyri Smith had never been with the neighborhood friend and was missing.
Police urge anyone seeing or knowing the whereabouts of Emyri Smith to contact the New Orleans Police Department at 504.821.2222.
Though Robert Pattinson stuck by her, Ben Affleck has left Kristen Stewart?in the dust. Citing a schedule crunch, the actor has backed out of?Focus, a con-artist movie set to costar Stewart and begin filming this spring. Stewart had just said in a recent interview that she was excited to start shooting, but now who knows what will happen. "Hi Kristen. We know that you were excited about working with Ben, but he dropped out, so we got you a replacement," a producer says to her the day she arrives on set. ...
If just one percent of drivers from commuter-heavy neighborhoods stayed off the road during rush hour, traffic congestion for everyone else would drop up to 18 percent, according to a first-of-its-kind analysis of cellphone data.
The finding provides a?convincing incentive for ?people in specific neighborhoods to take the bus, carpool or work from home, according to research leader Marta Gonzalez, a civil and environmental engineer at the Massachusetts Institute of Technology.?
Simply asking people in general?to take public transit or work remotely is ineffective,?Gonzalez told?NBC News. The study shows that it's best to convince a small number of drivers from a carefully?selected segment of the population to stay off the road during rush hour.
Going forward, the team aims to validate the findings on traffic simulators and then?work with city planners to carry out the one-percent plan ? that is, convince a small number of specific?people to stay home from time to time.
The breakthrough comes thanks to the team's access to cellphone data. Previously, studies like this relied on travel diary surveys, which limited the data to a?tiny fraction of commuters and a single day.?The cellphone data, by contrast, allowed the researchers to analyze trips taken by 100,000 people over the course of several weeks.
?That gives us very good statistics of the flows and, more importantly, if you see a congested street you can have a good estimate of where the drivers are coming from and that connection is what allowed us to design the strategy,? Gonzalez said.
She and colleagues analyzed three-weeks-worth of anonymous cellphone data from Boston and San Francisco to obtain information about drivers? routes, traffic volume, and speed on those routes. They were also able to determine the drivers? neighborhoods.
All of this data was combined with information on population density and the location and capacity of roads in the two cities. This allowed them to determine which neighborhoods are the largest sources of drivers on each road segment, and which roads these drivers use.
By cancelling one percent of trips by select drivers in a handful of neighborhoods in Boston would reduce traffic in the region by 18 percent. In San Francisco, the effect was a 14 percent reduction in congestion.
The data itself was made available to the researchers from mobile carriers, who collect the?information for billing and planning purposes. For example, knowing where most of their users travel in a day helps carriers decide where to build more cellphone towers, Gonzalez explained.
Her team's use of the data was subject approval of a review board that assured?the study did?not invade the privacy of individual users. ?We are not allowed to make a study that can follow individuals,? she noted.
Since the methodology of the study requires only access to anonymous cellphone data, information on population density and a road map, it can be easily replicated around the world, which the researchers are now doing with an aim to reduce traffic in?fast-growing cities.
The findings are reported today in the journal Scientific Reports.?
John Roach is a contributing writer for NBC News Digital. To learn more about him, check out his website. For more of our Future of Technology series, watch the featured video below.
I hope the guy quit while he was still ahead. Sliding off the road isn't nearly as bad as sliding into a creek.
BTW, that's a creek? Out here in the West, that'd be a full-blown river. A creek is something you can step (or at least walk) across. A river actually carries water.
Buy Real Marketing, the leading provider of web 2.0 business applications and social media solutions, launches Facebook service page. The service offers Facebook fans to boost clients? social media influence on the web.Ottawa, ON (PRWEB) December 19, 2012 BuyRealMarketing.com, the leading provider of web 2.0 business applications and social media solutions, recently launched the new webpage for service packages of Facebook fans that aim to help businesses gain traction in the online market, specifically within the giant social network of Facebook. ?
Original story here.
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The most famous alum of a chef training program in Chicago's Chinatown neighborhood never finished his classes at the Chinese American Service League's program, but Ivan Yuen still credits the course for his career.
The head chef of the lavish Shanghai Terrace fusion restaurant in the Peninsula Hotel has hired nearly half of his 12-person staff from the program.
"CASL teaches the very basics, to let the student understand a different culture," Yuen said.
Of the 1,400 students who have gone through the league's Chef Training Program since 1985, nearly 70 percent found jobs within six months.
With trainees landing in the kitchens of restaurants, hotels, hospitals, schools and food production outlets, program officials said the successful placement record stems from a network of about a dozen employers who continually use and trust the program, and alums, like Yuen, who believe in it.
The program was born from a need within the Chinese immigrant community in Chicago, said Ricky Lam, the nonprofit's employment and training department manager. The organization is one of many groups in the Chicago area supported by Chicago Tribune Holiday Giving, a campaign of Chicago Tribune Charities, a McCormick Foundation Fund.
"A lot of new immigrants go to work in restaurants, as a cook, dishwasher or waiter," Lam said.
Those jobs often went to the men in the family despite the low wages, long hours, little advancement and lack of benefits.
But women had an even tougher time finding work. Not only was there a language barrier, they also typically had to take care of young children or elderly relatives.
So CASL developed a comprehensive program that catered to the Chinese immigrant experience.
"It's very hard to be a new immigrant with a language barrier to start their career in America," Lam said. "(The program) needed to be very accessible and convenient for the community."
Translators are available in the training classes, which focus on Western cooking techniques and the basics. A pre-program English language class is offered as an option. The learning concludes with an introduction to job hunting, from writing resumes to interviewing.
The center also has in-house day care centers for children and elderly adults, with meals included. Stipends for transportation are available too.
The 16-week program runs year-round with up to 18 students in the cramped second-floor test kitchen, located at CASL's headquarters in Chinatown, 2141 S. Tan Court.
"Food service has always been in demand. People have to eat," Lam said.
Tuition is $5,000, but nearly all of the students are low-income adults living in the state who get their fees waived. The program itself is funded mostly by federal and state aid, with about 30 percent of its budget coming from foundation grants and donations.
The largest expense is the cost of food, but the students eat for lunch what they prepare and cook in class.
Leon Wei Long Mei moved to Chicago from China eight months ago and said he's already learned to make a very good Hollandaise sauce.
Although he's been working as a part-time restaurant busboy, the 29-year-old said he knew he needed a training program like CASL's to really start his life in America. Learning English remains his biggest obstacle.
"I think the question is not what I want to do, but if I had any opportunity, at my age, I should try," he said in Cantonese. "Every new place and each position will have more learning opportunities to make me better."
As for Yuen, he moved to the country in 1989 from China and worked in various kitchen jobs. His big break didn't come until about 10 years ago, when he left CASL's chef training program to take a line cook job at the then-relatively new Peninsula Hotel restaurant. His rank-and-file climb to the top of the kitchen command peaked in 2010, when he was named chef de cuisine.
He's always aspired to a high-profile job like the one he has now, he said, running a kitchen that serves an average of 150 guests a night and crafting special menus for Chicago's local elites and well-to-do visitors alike.
"When I was really young, I liked the cooking. I liked the eating," he said.
For more information on Chicago Tribune Charities, go to chicagotribune.com/holidaygiving.
The ability of browsers has come one such a long way in a short time. When I started creating websites (about 12 years ago), the most advanced visual features were the dreaded <blink> and <marquee> tags!
But now browser makers are pushing the?boundaries?with some?astonishing?experiments?in the browser. An amazing example of one of these is Chrome?s ?100,000 Stars?.
This?interactive?view of all the stars in our galaxy on Chrome?Experiments?is a stunning and mind blowing 3D?visualisation?of over 100,000 stars in our galaxy. In the past I?ve posted a couple of videos of incredible star-scapes ? but this is done all in the browser ? no video used!
You can take a tour through the galaxy ? zooming in on one of the stars that have already been studied in the galaxy (and amazingly small number!) or zoom out to see the whole of the milky-way.
To see the?experiment, you need a?browser?that supports ?Web GL? graphics. (and it?s a great reason to install Chrome if you haven?t already done so!)
Not only is this an incredibly inspiring look at ?our galatic corner? of creation, but as a web designer it?s very exciting to see what the capabilities of browsers and what we can now do in them!
WASHINGTON (Reuters) - A deal to avert a "fiscal cliff" of U.S. tax hikes and spending cuts looked closer on Tuesday after House of Representatives Speaker John Boehner kept the support of his Republican colleagues for compromises in talks with President Barack Obama.
Despite concerns of a revolt by Republicans in the House, Boehner emerged from a meeting with his members unscathed and pledged to press forward on negotiations with the White House. Boehner's concession last week to consider higher tax rates on the wealthiest Americans - an idea long fought by his party - signaled that a deal was possible ahead of a year-end deadline.
Republican Representative Darrell Issa, a key committee chairman, said House Republicans "were supportive of the speaker. ... I saw no one there get up and say, 'I can't support the speaker.'" Boehner is the top Republican in Congress.
Boehner told reporters after meeting his caucus - which includes a core of fiscal conservatives aligned with the Tea Party movement opposed to tax hikes - that Obama's latest offer on taxing the wealthiest Americans is "not there yet," but he remained hopeful of an agreement.
In a major concession to Republican demands, Obama on Monday offered to set a $400,000 threshold for incomes that would face tax increases with the expiration at the end of the year of low tax rates enacted under former President George W. Bush.
Obama had previously insisted on setting the threshold at $250,000. Boehner has been seeking a level of $1 million. Analysts said the two may compromise on $500,000.
Obama and Boehner are working to avert steep tax hikes and deep spending cuts set to begin taking effect next month. Known as the "fiscal cliff," the measures could trigger another recession, economists warn.
As negotiations have largely overcome ideological differences and turned to increasingly narrow disagreements over numbers, markets turned upward on hopes of a deal.
World shares moved toward a three-month high on Tuesday and weakened appetite for safe-haven bonds and the dollar. The benchmark Dow Jones industrial average of 30 major U.S. industrial stocks was up less than 1 percent. The gain followed a steep rally in the previous session.
'PLAN B'
As both parties tried to digest details of a possible agreement, Boehner put forward what he called "Plan B" legislation. If brought to the House floor, the bill would let Republicans show that they worked to keep income tax rates low on most Americans. For weeks they have feared a public backlash against them if tax rates rise on January 1.
Boehner said a vote on a Republican bill along these lines could come as early as this week in the House.
Obama could face unrest from rank and file fellow Democrats. Liberal Democrats are likely to oppose a key compromise he has offered to permit shrinking cost-of-living increases for all but the most vulnerable beneficiaries of the Social Security retirement program.
The president's proposal calls for using a different formula, known as "chained Consumer Price Index," to determine the regular cost-of-living increases and essentially reduces benefits.
Obama on Monday conceded allowing the extension of low income tax rates begun during the Bush administration for incomes up to $400,000 per household. He had previously insisted setting that cut-off at $250,000.
Boehner had earlier conceded to agreeing that Bush-era tax rates can expire for the wealthiest Americans, after opposing for months tax rate increases of any kind. He proposed setting a $1 million income threshold for raising rates.
Some analysts expect a compromise could come at $500,000. "That still looks like a safe bet," said Greg Valliere, chief political strategist at Potomac Research Group.
Obama also moved closer to Boehner on the proportion of a 10-year deficit reduction package that should come from increased revenue, as opposed to cuts in government spending. Obama is now willing to accept a revenue figure of $1.2 trillion, down from his previous $1.4 trillion proposal.
Boehner's latest proposal calls for $1 trillion in new tax revenue from higher tax rates and the curbing of some tax deductions taken by high-income Americans.
Missing from Obama's latest offer was any extension of the so-called "payroll tax holiday" that ends on January 1, bringing an immediate tax increase on wage earners.
A Republican aide who asked not to be identified said that "conceptually" there was agreement to make permanent changes in the tax code, with some of those changes taking effect at the start of 2013 and others at the beginning of 2014.
A thorough cliff-avoiding agreement could immediately substitute more targeted spending cuts for the indiscriminate slashing of programs known as "sequestration."
Possible plans to produce cuts in spending for Medicare and Medicaid, the government health insurance programs for seniors and low-income Americans respectively, remained to be discussed.
Boehner and Obama have made headway on the politically explosive question of the president's ability to avoid constant battles over raising the nation's debt ceiling, which controls the level of borrowing by the government. Boehner is ready to give Obama a year of relative immunity from conservative strife over the debt ceiling, while Obama is pushing for two years.
(Additional reporting by David Lawder, Kim Dixon and Fred Barbash; Writing by Kevin Drawbaugh; Editing by Alistair Bell and Will Dunham)
(Reuters) - A U.S. judge on Monday denied Apple Inc's request for a permanent injunction against Samsung Electronics' smartphones, depriving the iPhone maker of key leverage in the mobile patent wars.
Apple had been awarded $1.05 billion in damages in August after a U.S. jury found Samsung had copied critical features of the iPhone and iPad. The Samsung products run on the Android operating system, developed by Google.
Apple and Samsung are going toe-to-toe in a patents dispute that mirrors the struggle for industry supremacy between the two companies, which control more than half of worldwide smartphone sales.
For most of the year, Apple had been successful in its U.S. litigation campaign against Samsung. Apple convinced U.S. District Judge Lucy Koh in San Jose, California to impose two pretrial sales bans against Samsung -- one against the Galaxy Tab 10.1, and the other against the Galaxy Nexus phone.
Apple then sought to keep up the pressure after its sweeping jury win. It asked Koh to impose a permanent sales ban against 26 mostly older Samsung phones, though any injunction could potentially have been extended to Samsung's newer Galaxy products.
Yet the jury exonerated Samsung on the patent used to ban Galaxy Tab 10.1 sales, and Koh rescinded that injunction. Then, in October, a federal appeals court reversed Koh's ban against the Nexus phone.
In her order late on Monday, Koh cited that appellate ruling as binding legal precedent, ruling that Apple had not presented enough evidence that its patented features drove consumer demand for the entire iPhone.
"The phones at issue in this case contain a broad range of features, only a small fraction of which are covered by Apple's patents," Koh wrote.
"Though Apple does have some interest in retaining certain features as exclusive to Apple," she continued, "it does not follow that entire products must be forever banned from the market because they incorporate, among their myriad features, a few narrow protected functions."
An Apple spokeswoman declined to comment on Koh's ruling, and a Samsung representative could not immediately be reached.
In a separate order on Monday, Koh rejected a bid by Samsung for a new trial based on an allegation that the jury foreman was improperly biased in favor of Apple.
The case in U.S. District Court, Northern District of California is Apple Inc. vs. Samsung Electronics Co Ltd et al, 11-1846.
(Reporting by Dan Levine in Oakland, California; Editing by Ron Popeski)
HARTFORD, Conn. (AP) ? Weapons used by Connecticut gunman Adam Lanza, who killed 20 children and six school workers Friday after killing his mother at their home. Lanza committed suicide in Sandy Hook Elementary School.
The primary murder weapon:
? Bushmaster AR-15 rifle, a civilian version of the military's M-16 and a model commonly seen at marksmanship competitions. It's similar to the weapon used in a recent shopping mall shooting in Oregon. Two men convicted in a series of sniper killings in the Washington, D.C.-area in 2002 also used a Bushmaster .223-caliber rifle that they fired from the trunk of a car at randomly picked victims. Lanza was carrying multiple 30-round magazines, police said, though higher capacity ones are available.
Also found in the school near Lanza's body:
? Glock 10 mm: A larger and more powerful weapon than the widely popular 9 mm, it is in many respects similar to the 9 mm. It is a lightweight and comparatively affordable weapon that is often used for target shooting and for personal protection. Lanza killed himself with a shot to the head from this pistol, according to a state official who spoke on condition of anonymity because the source was not authorized to disclose details of the investigation.
? Sig Sauer 9 mm: Considered an upper-tier, quality product, it's comparatively expensive, and its range of uses includes elite military and police units.
Found in the vehicle Lanza drove to the school:
? A fourth weapon, a shotgun.
Also:
? The gunman's mother was found dead in her pajamas in bed, shot four times in the head with a .22-caliber rifle, said the Connecticut official who spoke on condition of anonymity.
The negotiations in the antitrust case between Google and the U.S. Federal Trade Commission is reportedly drawing to a close, with things looking up for Google, according to reports. The Wall Street Journal said that the FTC could agree to end its investigation as early as this week after Google voluntarily agreed to allay the agency's concerns by making some changes to it search practice.
LocalUncle, a real-time location-based Q&A iPhone app, has relaunched with a new version -- offering faster tech and a cleaner interface in a bid to grow enough users to power its service. The original app launched back in November 2011 but didn't achieve enough user traction to live up to the app maker's grand plan of building a mobile user-to-mobile user Q&A platform.
Are you aware that diet and dietary inadequacies would be the major reason for most health problems? The very best 3 main reasons for dying within this country ? cardiovascular disease, cancer and stroke ? are mainly avoidable with diet and diet alone! For this reason so many people are seeking alternative health care today.
It is crucial that you consume correctly. Even though you might be a little kind of dietary supplementation, it is definitely a alternative for food. People require food. We can not manufacture our very own food. It might be wonderful when we could, however, we?re needed to really eat and process meals to obtain the appropriate nutrition essential for existence.
Most of us have been expected to follow a respectable diet or told to consume right, but we?re never told precisely what that?s. That may be construed in a different way for everybody person. It might mean do not eat fried meals for just one person as well as for another it might mean to consume a vegetarian type diet. Let us have a look at diet. You?re things to eat!
Diet may be the science from the relationship of meals and nutrition to health insurance and disease. It?s a very complex science including over 40 different nutrition. Diet is very important for each age bracket. It is crucial for potential to deal with disease and ale your body to heal and repair. Optimal diet can also be required for normal development, reproduction as well as for growth.
Nutrition fall under six groups: carbohydrates, fats, protein, vitamins, minerals, and water.
Let us discuss vitamins. Vitamins are crucial for growth, protection and also the regulating energy in the human body. They ought to be provided by diet. An insufficiency inside a particular vitamin can ultimately increase the risk for expression of signs and symptoms. Vitamins perform specific roles in the human body and could be further split into two groups, body fat-soluble and water-soluble. The body fat-soluble vitamins are vitamins A, D, E and K. Body fat-soluble vit a was the very first vitamin recognized. Your body more readily soaks up this group when consumed with body fat or oils. These vitamins are saved in your body and do not need to always be consumed daily. Water-soluble group includes the Vitamin b, which encompass the whole B complex including B2, B2, B3, B6, B12, folate, pantothenic acidity and biotin in addition to ascorbic acid.
As very important because it is that you should consume appropriate meals, this may also be necessary that you should likewise invest in taking some type of vitamin supplementation. The meals that people eat today doesn?t have exactly the same mineral and vitamin content it did years back. There?s a stable and rapid depletion from the soil where crops are grown creating lack of minerals and vitamins. Like a matter fact to obtain the equivalent iron which was in a single cup of green spinach in 1945 you would need to eat 65 cups today! Also many crops cannot even absorb minerals in the soil because of chemical manure. One other issue today may be the genetic modification of meals. Genetically changed meals could have genes using their company plants or creatures they might even contain chemicals for example pesticide sprays.
There?s a business which has isolated the gene in seafood that safeguards them from cold and it has integrated that gene right into a tomato. A lot of you understand the remembered taco shells in the past simply because they were contaminated using the genetically changed corn named ?Starlink? that was modified to create its very own pesticide sprays. Over 70% from the corn crop continues to be genetically designed. This corn is lacking of b12 along with other compounds. Obviously supplementation ought to be incorporated inside your daily diets, but from the natural source.
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Tags: Vegetables And Fruits, Vegetables And Fruits healthy life This entry was posted on Sunday, December 16th, 2012 and is filed under Health Tips, Nutrition. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.