Tuesday, October 25, 2011

Janet Jackson reschedules shows to be with family (AP)

NEW YORK ? Janet Jackson is rescheduling part of her Australian tour so she can support her family during the trial of the doctor accused of involuntary manslaughter in her brother Michael's death.

Dr. Conrad Murray is on trial in Los Angeles. He is accused of being negligent in his care of the superstar, who died in 2009 of an overdose of the anesthetic propofol at age 50.

The prosecution is wrapping up its case this week, and the defense is about to present its case. The Jacksons have been a regular presence at the trial; Janet Jackson was there at the beginning.

"When I planned these shows, the schedule in California was completely different," she said in a Sunday statement to The Associated Press. "After talking with my family last night, I decided we must be together right now. .... This saddens me in so many ways."

The shows for her "Number Ones" tour were scheduled in Melbourne on Wednesday, Thursday and Saturday; to make them up, she'll perform one night, on Nov. 3, in Rod Laver Arena. She thanked her fans for their support and understanding.

Jackson also has the support of her promoter.

"It is important that Janet is with her family at this critical point in the hearing. While Janet and our company apologize for any inconvenience for the reschedule of the Melbourne shows, we thank Janet for the great and successful concerts in Perth and Adelaide and eagerly await her return. ... Our thoughts and prayers are with Janet and the entire Jackson family," promoter Paul Dainty said.

___

Online:

http://www.janetjackson.com

___

Nekesa Mumbi Moody is the AP's music editor. Follow her at http://www.twitter.com/nekesamumbi

Source: http://us.rd.yahoo.com/dailynews/rss/music/*http%3A//news.yahoo.com/s/ap/20111024/ap_en_mu/us_people_janet_jackson

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Hollye Harrington Jacobs: A Fashionable and Informative Trip to Chemotherapy (Huffington post)

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Monday, October 24, 2011

Water disinfection byproducts linked to adverse health effects

ScienceDaily (Oct. 24, 2011) ? University of Illinois scientists report the first identification of a cellular mechanism linked to the toxicity of a major class of drinking water disinfection byproducts. This study, published in Environmental Science & Technology, suggests a possible connection to adverse health effects, including neurological diseases such as Alzheimer's.

"I'm not implying that drinking disinfected water will give you Alzheimer's," said Michael Plewa, lead scientist and professor of genetics in the U of I Department of Crop Sciences. "Certainly, the disinfection of drinking water was one of the most significant public health achievements of the 20th century. But the adverse effects of disinfection byproducts (DBPs) that are unintentionally formed during this process are causing concerns as researchers unveil their toxicity."

More than 600 DBPs have been discovered. Although researchers know some DBPs are toxic, little biological information is available on the majority of these water contaminants. The Environmental Protection Agency regulates only 11 of these DBPs, he said.

Plewa's laboratory investigated the biological mechanism, or the cellular target that leads to toxicity, in the second-most prevalent DBP class generated in disinfected water -- haloacetic acids (HAAs).

"The EPA has regulated HAAs for nearly 15 years. However, we did not know how they caused toxicity before this study," he said. "Now that we've uncovered the mechanism for HAAs, we can make sense of past data that can lead to new studies relating to adverse pregnancy outcomes, different types of cancer, and neurological dysfunction."

Plewa believes this will assist the EPA in establishing regulations based on science. Their research will also help the water treatment community develop new methods to prevent the generation of the most toxic DBPs.

"It's fairly simple," Plewa said. "To increase the health benefits of disinfected water, we must reduce the most toxic DBPs. If we understand their biological mechanisms, we can come up with more rational ways to disinfect drinking water without generating toxic DBPs."

In this study, researchers focused on three HAAs -- iodoacetic acid, bromoacetic acid and chloroacetic acid. After they rejected their first hypothesis that the HAAs directly damaged DNA, they looked at research in a different area -- neuroscience. Plewa's graduate student, Justin Pals, discovered an amazing connection, Plewa said.

In neurotoxicology, iodoacetic acid reduces the availability of nutrients or oxygen in neurons by inhibiting glyceraldehyde-3-phosphate dehydrogenase (GAPDH).

"Researchers are interested in understanding how to prevent damage after a stroke or other neurological damage," Plewa said. "Iodoacetic acid kills these cells. One of the targets they found was that iodoacetic acid inhibited GAPDH."

Plewa's lab conducted quantitative GAPDH enzyme kinetics and discovered that the data were highly correlated with a diversity of adverse health markers.

"All the pieces of the puzzle fell into place in an instant," Plewa said. "We had discovered our cellular target -- GAPDH. Never before had this type of research been done with this level of precision and associated with a large body of adverse biological impacts."

They discovered that the HAA disinfection byproducts were toxic because the cells cannot make ATP, and this causes oxidative stress.

"Cells treated with HAAs experience DNA damage," Plewa said. "So they start expressing DNA repair systems. HAAs are not directly damaging DNA, rather they are inhibiting GAPDH, which is involved in increasing the oxidative stress that we are observing."

A growing body of information has shown that GAPDH is associated with the onset of neurological diseases.

"If you carry a natural mutation for GAPDH and are exposed to high levels of these disinfection byproducts, you could be more susceptible to adverse health effects such as Alzheimer's," he said.

More research is needed to study iodinated disinfection byproducts because they are the most reactive in inhibiting GAPDH function and are currently not regulated by the EPA, Plewa said.

"We replaced the standard working model of direct DNA damage with a new working model based on a cellular target molecule," he said. "This discovery is a fundamental contribution to the field of drinking water science."

This research was published in Environmental Science & Technology. Scientists include Michael Plewa, Justin Pals, Justin Ang and Elizabeth Wagner, all of the University of Illinois. Research was supported by the WaterCAMPWS Center NSF Award CTS-0120978.

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Story Source:

The above story is reprinted from materials provided by University of Illinois College of Agricultural, Consumer and Environmental Sciences. The original article was written by Jennifer Shike.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Justin A. Pals, Justin K. Ang, Elizabeth D. Wagner, Michael J. Plewa. Biological Mechanism for the Toxicity of Haloacetic Acid Drinking Water Disinfection Byproducts. Environmental Science & Technology, 2011; 45 (13): 5791 DOI: 10.1021/es2008159

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://www.sciencedaily.com/releases/2011/10/111024153450.htm

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Video: Obama shifts conversation back to jobs

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Source: http://www.msnbc.msn.com/id/21134540/vp/45000069#45000069

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[TUTORIAL] Como configurar o iCloud no seu PC com Windows

Um dos carros chefes do sistema iOS 5 ? o?iCloud, que permite sincronizar dados e imagens na nuvem e acess?-los tanto no computador quanto no iPhone, iPad ou iPod touch. Mas muitos instalaram o sistema e n?o conseguiram ainda aproveitar toda a potencialidade, por n?o saber configurar o seu PC. De fato, enquanto no Mac ? tudo integrado ao sistema Lion, no Windows a instala??o n?o ? autom?tica e exige que voc? inclua alguns itens extras no seu computador.

Se voc? ainda n?o conseguiu fazer isso, veja agora o passo a passo.

?

1.?Baixe o Painel de Controle

Para integrar o iCloud ao seu sistema Windows, voc? precisa baixar e instalar um painel de controle gratuito disponibilizado pela Apple. A primeira m? not?cia: este painel de controle s? funciona nas vers?es mais modernas do sistema da Microsoft (Vista ou 7), deixando quem tem XP de fora.

Para baixar o painel, em portugu?s, siga este link:?Painel de Controle iCloud para Windows

2. Ative o iCloud no computador

Para criar uma conta no iCloud, voc? tem que ter obrigatoriamente um Mac ou um?dispositivo iOScom o iOS 5. N?o ? poss?vel fazer isso diretamente pelo Windows.

Depois de criado o seu ID, ? hora de ativ?-lo no computador. V? no menu?In?cio?do Windows (aquele no canto inferior esquerdo da tela) e selecione?Painel de Controle > Rede e Internet > iCloud, onde voc? poder? configurar a sincroniza??o com fotos, contatos, favoritos, emails, calend?rios e lembretes. Mas a? vem a segunda m? not?cia: para sincronizar contatos, calend?rios e lembretes, voc? precisa obrigatoriamente ter o?Microsoft Office?(oh, mundo ir?nico) 2007 ou 2010 instalado, sen?o nada feito. Se voc? ? um dos que n?o tem, s? poder? sincronizar as fotos e os favoritos, isso se tiver instalado ou o?Safari 5.1.1 ou o Internet Explorer 8.


S? quem tem a ?ltima vers?o dos programas para poder aproveitar todo o iCloud

3. Habilite os downloads autom?ticos no iTunes

Se voc? ainda n?o fez, pode ativar os downloads autom?ticos no iTunes, para que tudo o que voc? baixe em um lugar v? automaticamente para todos os seus dispositivos. Para fazer isso, voc? obrigatoriamente precisa atualizar o?iTunes?para a vers?o 10.5 (coisa que voc??j? deve ter feito?se j? tem o iOS 5 instalado).

Depois, abra o aplicativo e v? no menu?Editar > Prefer?ncias?(no Mac ? iTunes > Prefer?ncias), na aba?Loja?e selecione?Aplicativos?e?Livros, para que o download aconte?a tamb?m no computador.

Com todos estes passos, voc? j? est? apto a come?ar a sincronizar suas informa??es entre o computador e seus dispositivos. Nos pr?ximos artigos, daremos mais explica??es de como aproveitar do melhor do iCloud.?;)

[blogdoiphone]

Source: http://feedproxy.google.com/~r/osxbr/news/~3/NzbthAFxsQo/

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Sunday, October 23, 2011

Occupy Chicago: 130 arrested in city park protest

Protesters prepare to be arrested during an Occupy Chicago march and protest at Grant Park in Chicago, late Saturday, Oct. 22, 2011. (AP Photo/Paul Beaty)

Protesters prepare to be arrested during an Occupy Chicago march and protest at Grant Park in Chicago, late Saturday, Oct. 22, 2011. (AP Photo/Paul Beaty)

A protester gets arrested during an Occupy Chicago march and protest in Grant Park in Chicago, Sunday, Oct. 23, 2011. Demonstrators of the anti-Wall Street group Occupy Chicago stood their ground in a downtown park and defied police orders to clear the area, prompting police to make more than a dozen arrests early Sunday. (AP Photo/Paul Beaty)

A protester gets arrested during an Occupy Chicago march and protest in Grant Park in Chicago, Sunday, Oct. 23, 2011. Demonstrators of the anti-Wall Street group Occupy Chicago stood their ground in a downtown park and defied police orders to clear the area, prompting police to make more than a dozen arrests early Sunday. (AP Photo/Paul Beaty)

A protester gets arrested during an Occupy Chicago march and protest in Grant Park in Chicago, Sunday, Oct. 23, 2011. Demonstrators of the anti-Wall Street group Occupy Chicago stood their ground in a downtown park and defied police orders to clear the area, prompting police to make more than a dozen arrests early Sunday. (AP Photo/Paul Beaty)

Protesters gather at night in Grant Park during an Occupy Chicago march and protest, Saturday, Oct. 22, 2011, in Chicago. Protesters led a slow march from Chicago's financial district Saturday, taking more than 45 minutes to reach the park. Along the way, police on horses blocked marchers from walking on the street on Michigan Avenue, leaving them with just the sidewalks to occupy. (AP Photo/Paul Beaty)

(AP) ? Anti-Wall Street demonstrators of the Occupy Chicago movement stood their ground in a downtown park in noisy but peaceful defiance of police orders to clear out, prompting 130 arrests early Sunday, authorities said.

Occupy Chicago spokesman Joshua Kaunert vowed after the arrests that protests would continue in the Midwest city.

"We're not going anywhere. There are still plenty of us," Kaunert told The Associated Press after the arrests, which took police more than an hour to complete.

Elsewhere in the nation, police reported 11 arrests overnight in the Occupy Cincinnati protests. Police said those arrested had stayed in that city's Fountain Square after Sunday's 3 a.m. closing time and each was charged with criminal trespass.

In Chicago, police began taking people into custody just before 1 a.m. Sunday. Those arrested were led in groups to vans and two large white buses as others clamored to be arrested.

"Take me next! Take me next!" some shouted as police began the arrests. Others chanted as they were led away: "We'll be back!"

Officers had begun placing metal barricades around the area of Chicago's Grant Park known as Congress Plaza about 11:10 p.m. Saturday, minutes after the park had closed. Afterward, police then went through the crowd and warned people to leave or risk arrest for remaining in the closed park in violation of a city ordinance.

Several of the protesters who stayed inside the barricades in the park sat on the ground. Others locked arms as police circled and then began arresting people.

"One: We are the people! Two: We are united! Three: The occupation is not leaving!" demonstrators shouted. Others joined in from just outside the park.

Chicago police said Sunday morning that 130 arrests had been made.

Kaunert said none of those arrested had resisted.

"Everybody was very peaceful and smiling and there was no violence, though a lot of chanting," he said.

He urged authorities to let the people resume protesting peacefully against the perceived greed and other ills they see on Wall Street and elsewhere in corporate America. He noted it was the second straight weekend that arrests had been made in the park after 175 arrests the previous Sunday after protesters set up tents past public hours.

"The police came in and again took away our right to free speech and assembly," he said. "Several paddywagons left and they had two very large prison buses and those are gone now."

Paulina Jasczuk, a 24-year-old dental receptionist, watched as her boyfriend, Philip Devon, was led away in the night hours. She threw him a white sweater against the chill of a fall night in Chicago.

"I'm proud of everyone who got arrested tonight," she told AP, adding she hoped they would inspire more demonstrators to join in the movement in the weeks ahead.

Demonstrators were taken away one by one and handcuffed with white plastic ties and. Some on the scene shouted: "This is what democracy looks like!"

Drums banged and some people clanged on metal.

Jonathan Sumner, 25, of Chicago, watched the arrests from outside the park and began shouting at officers: "Why are you doing this?"

"It's a sad day for the CPD" he said, referring to the Chicago Police Department.

Some said earlier that arrests only signal the importance of the Occupy movement.

"This movement will not be a serious movement until we take a stand, and getting arrested is just one way of taking a stand," said Max Farrar, 20, a junior political science major at DePaul University, speaking Saturday to a reporter.

About 1,500 people gathered for the protest that began Saturday. Demonstrators descended on the city park with hopes of making it the movement's permanent home. The group had started in Chicago's financial district before marching to the park.

Along the way, marchers chanted "Banks got bailed out, we got sold out!" and held signs that read "Greed Sucks" and "No War But The Class War" while police on horses blocked them from walking on the street on Michigan Avenue, leaving them with just the sidewalks to occupy.

Occupy Wall Street began a month ago in New York among a few young people, and has grown to tens of thousands around the country and the world.

In Cincinnati, Police Capt. Doug Wiesman said early Sunday that the 11 arrests carried out there were "straightforward" and without problems. A protester, Aaron Roco, told AP about 30 other protesters who remained on a sidewalk just outside the Cincinnati square during the police action weren't arrested.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2011-10-23-Wall%20Street%20Protest-Chicago/id-5377b75a7dc94a72b212588ee6b0a259

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Cards, Rangers hoping to go batty in World Series

Texas Rangers' Michael Young takes batting practice Friday, Oct. 21, 2011, in Arlington, Texas. The Rangers are scheduled to play the St. Louis Cardinals in Game 3 of baseball's World Series on Saturday. (AP Photo/Tony Gutierrez)

Texas Rangers' Michael Young takes batting practice Friday, Oct. 21, 2011, in Arlington, Texas. The Rangers are scheduled to play the St. Louis Cardinals in Game 3 of baseball's World Series on Saturday. (AP Photo/Tony Gutierrez)

St. Louis Cardinals' Lance Berkman stretches at the start of practice Friday, Oct. 21, 2011, in Arlington, Texas. The Cardinals will play the Texas Rangers in Game 3 of baseball's World Series on Saturday. (AP Photo/Tony Gutierrez)

St. Louis Cardinals manager Tony La Russa walks onto the field during practice at baseball's World Series Friday, Oct. 21, 2011 in Arlington, Texas. The Texas Rangers are scheduled to play the Cardinals in Game 3 on Saturday. (AP Photo/Tony Gutierrez)

Texas Rangers' Adrian Beltre shows off his ripped batting glove to teammates after taking a few swings during practice Friday, Oct. 21, 2011, in Arlington, Texas. The Rangers are scheduled to play the St. Louis Cardinals in Game 3 of baseball's World Series on Saturday. (AP Photo/Tony Gutierrez)

(AP) ? Strolling behind the batting cage, Matt Holliday watched his St. Louis teammates hit away Friday and offered a simple tip.

"Get a good swing!" he hollered.

Great advice for anyone with a Louisville Slugger in hand at this World Series.

Despite the presence of Josh Hamilton, Albert Pujols, Nelson Cruz and other top boppers, the Cardinals and Texas Rangers have hardly dented the scoreboard while splitting the first two games.

So far, a total of just eight runs. The last time there were fewer through the opening two games at a Series? Try 1950, when Joe DiMaggio and the New York Yankees combined with Philadelphia for four.

"A lot of people thought this was going to be an offensive World Series," Texas shortstop Elvis Andrus observed before an off-day workout.

Blame the drought on a few factors: raw weather at Busch Stadium, good pitching and, perhaps most significantly, hitters facing arms they've never seen before.

Both teams have flailed away at the plate, chasing sliders and curves that bounced, shattering bats and seeming to guess wrong on what pitches were coming next.

"We need to give good at-bats and get deeper and quit swinging at balls out of the strike zone," Mike Napoli said.

Napoli has hit the lone home run of the Series. He connected off Chris Carpenter, but maybe he had an edge ? Napoli had been 3 for 3 lifetime against the Cardinals ace going into Game 1.

Fresh off their two-run rally in the ninth inning and a 2-1 win in Game 2, the Rangers start Matt Harrison on Saturday night at Rangers Ballpark. Kyle Lohse will pitch for the Cardinals.

"It's a tough place to pitch, especially when you see those flags blowing in. It usually means that jet stream is going to right-center," Lohse said. "I think everyone in the league knows that."

Each team adds a designated hitter, with the AL rule in effect at Texas. Cardinals manager Tony La Russa will make Lance Berkman the DH and put Allen Craig ? already with a pair of key pinch-hit RBI singles ? in right field.

The Rangers will likely use Michael Young at DH, move Napoli to first base and put Yorvit Torrealba at catcher.

At this point, it might take more than a wind tunnel to help the hitters.

Texas is batting only .186, St. Louis is stuck at .203. Hamilton and Pujols are hitless, and Cruz has been held to a mere single after tearing through the AL championship series.

On Friday, Cruz gave the Hall of Fame the bat he used to hit a grand slam in the ALCS. It was cracked ? maybe Texas and St. Louis need new timber, too.

It seemed fitting, in fact, that when Texas scored those two runs Thursday night to even the Series, both crossed on sacrifice flies.

Each team has scored four runs overall. Back in 1983, Baltimore and Philadelphia also combined for eight through two games ? it's more than 60 years since the total was lower than this October.

"I think honestly we got out of our approach a little bit, maybe a little over aggressive trying to create things that necessarily weren't there," said Ian Kinsler, whose bloop single and daring steal keyed the Texas comeback. "If we can just relax and play our style of baseball, let the game come to us, we'll be all right."

Rangers outfielder David Murphy hopes it plays out that way, eventually.

"It's the World Series. We're going to face a guy tomorrow that most of us have never faced, if at all. Game 4 is a little different because Edwin Jackson has been in the American League enough to where most of us have probably faced him," he said.

"I feel like just watching the first two games, offensively, it's just a matter of who is going to make adjustments on the fly. We're facing their guys that we've never before and it's the same thing on their side. The pitching performances have been good, but we have confidence in our offense to put up runs, as well," he said.

So does Texas hitting coach Scott Coolbaugh. He was promoted from the Triple-A job when Thad Bosley was fired two months into his first year with the team.

Coolbaugh watched Young swing through strike three from Jaime Garcia in Game 2, then saw Adrian Beltre wave at a couple of low off-speed deliveries.

"I think it was evident that some of our guys were seeing someone for the first time," Coolbaugh said. "You can watch all the video you want and read all the scouting reports. But when you step into that batter's box, it all looks different."

Coolbaugh, however, was not surprised when the Rangers put together better at-bats in the ninth against Jason Motte and the St. Louis bullpen.

"That was two days in a row that we were seeing their relievers. The more we see them, the better off we'll be," he said.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2011-10-21-BBO-World-Series/id-d80d31cd84d54a8abc37d212fd7bafba

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